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Cooperative Agreement to a USA Agency, Nonprofit, For-Profit, or IHE to Oversee and Coordinate a Cancer Research Network

NCI Cancer Screening Research Network: Coordinating and Communication Center (UG1 Clinical Trial Required)

GrantWatch ID# 207845
Agency: Federal

Funding Source
U.S. Department of Health and Human Services (HHS) - National Cancer Institute (NCI)
CFDA Number: 93.393, 93.394, 93.399
Funding or PIN Number: RFA-CA-23-022
Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

Geographic Focus
USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);

Important Dates
LOI Date: 01/28/23
Deadline: 02/28/23 5:00 PM Applicant's Local Time Save

Grant Description
Cooperative agreement to a USA or territories entity that provides healthcare, including an agency, Tribe, nonprofit or for-profit organization, or IHE, to oversee and coordinate a cancer research network. Applicants are advised that required registrations may take several weeks to complete.

The primary goal of the Cancer Screening Research Network (CSRN) is the conduct of multi-center cancer screening trials and studies. This Network is designed to take advantage of large and diverse populations receiving routine care in a variety of healthcare settings. The CSRN will engage these populations in rigorous studies focused on cancer screening to improve early cancer detection and evaluate emerging cancer screening modalities with the ultimate goal of reducing cancer incidence, and cancer-related morbidity and mortality.

CSRN Coordinating and Communication Center (CCC) will provide cancer screening expertise and clinical trial leadership and is responsible for the coordination of all aspects of study operations, as well as the development and implementation of communication activities.

To support the CSRN goals, the CCC will be expected to have the expertise and capacity to contribute the following:

  • Provide scientific leadership in the overall development, conduct, and coordination of cancer screening clinical trials and observational studies within the CSRN.
  • Work collaboratively with the NCI program staff in the creation and management of study operations including the development and implementation of communication activities for trials and studies.
  • Develop and implement trial-specific participant recruitment and retention strategies. This includes devising specific recruitment approaches for underrepresented populations including racial, ethnic, and religious minorities, rural populations, and others.
  • Develop participant-facing materials in plain language and sensitive to specific populations as necessary for trial recruitment and retention.
  • Develop and update the trial information website.
  • Produce and distribute messages and graphics appropriate for use by ACCESS Hubs on a variety of social media platforms with translations to languages other than English.
  • Coordinate protocol development and management for the CSRN including the Vanguard pilot study. Trial design activities will be undertaken in collaboration with the NCI program staff, SDMC, and ACCESS Hubs. NCI will review and have final approval for the trial protocol and all subsequent amendments.
  • Ensure compliance with NIH, FDA, OHRP, and other federal requirements.
  • Conduct audits and site visits of ACCESS Hubs and Affiliate Organizations.
  • Coordinate specimen collection for biobanking.
  • Work collaboratively and in an integrated manner with the SDMC and ACCESS Hubs.
  • Facilitate the development and management of a Participant Advisory Committee.
  • Develop affiliation agreements with each ACCESS Hub, its affiliate organizations, and the SDMC.
  • Provide education, training, and support to ACCESS Hubs and monitor and evaluate the performance of the individual ACCESS institutions. Together with the SDMC, the CCC will monitor and evaluate the diversity of the participant population and tailor strategies for recruitment and retention to improve the diversity of the participant pool.
  • Provide support for ACCESS Hubs to integrate new investigators and institutions into the NCI rostering system.
  • Plan and facilitate meetings for the Network Steering Committee and any subcommittees or working groups under the Steering Committee. The Steering Committee will include members from all components of the Network and the NCI program staff.
  • Facilitate the development of the Data Safety Monitoring Board for trials and other Network activities for CSRN studies.
  • Interact with companies providing materials to CSRN trials, and, in consultation and collaboration with NCI program staff, participate in the technology assessment and selection process. For example, the CCC may participate in the MCD assay evaluation and selection process for participation in a CSRN study.
  • Collaborate with the SDMC and ACCESS Hubs to develop and implement the Vanguard pilot study. This protocol will be developed with the close involvement of NCI staff and its results will inform the design of future large-scale clinical trials.


  • City or township governments
  • County governments
  • For profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Others (see text field entitled "Additional Eligibility Criteria" for clarification)
  • Small businesses
  • Special district governments
  • State governments

Additional Eligibility Criteria
Eligible Organizations:
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations

An eligible institution/organization for the purposes of this application is defined as a healthcare providing entity including, but not limited to, a consortium of academic and community institutions, a healthcare system, practice-based research network, or other institution providing direct medical care to patients that are considered one integral organizational entity under a single financial management system and governance structure.

Applicants that contain multiple types of eligible institutions are welcome to apply.

Only one application per institution is allowed.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

The following types of activities remain outside the scope of this FOA, and applications proposing them are non-responsive to this FOA and will not be reviewed:
- Evaluating technology for the purpose of detecting the recurrence of previously treated cancers.
- Applications that do not address NCI’s scientific mission.

Pre-Application Information
- Letter of Intent Due Date: January 28, 2023
- Application Due Date: February 28, 2023
- Scientific Merit Review: July 2023
- Advisory Council Review: October 2023

All applications are due by 5:00 PM local time of applicant organization.

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Applicants may submit applications via the NIH ASSIST system or via Workspace.

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.
- System for Award Management (SAM)
- eRA Commons

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For a list of relevant application documents, go to the Package tab (press Preview) on the link above.

Additional Funding Information

Estimated Total Program Funding:


Number of Grants

Estimated Size of Grant

Term of Contract
The maximum project period is 4 years.

Earliest Start Date: December 2023

Contact Information
The letter of intent should be sent to:
Paul Pinsky, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-7014

ASSIST online application platform: Customer Support (Questions regarding registration and Workspace)
Contact Center Telephone: 800-518-4726

Scientific/Research Contact(s):

Paul Pinsky, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-7014

Elyse LeeVan, M.D.
National Cancer Institute (NCI)
Telephone: 240-276-7314

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